The 49ers Offensive line will have to play to a perfection to fight off the Giants fierce Defensive line and pass rushers.
On the other side of the ball the Giants Offensive line hasn't looked too strong this year and with the 49ers Defensive Line and Pass Rushers playing very well its likely that Eli will be getting reintroduced to the Candlestick grass.
I do expect this to be a dog fight, the best defensive stand will lead to the winner in this game. The 49ers can win this game as long as they play focused and aren't focused on revenge.
Ok so here's the rest of my picks.
Steelers over Titans - The Titans haven't been able to get anything going yet this year. Maybe if they rush the ball 30 times and get CJ going this will be competitive other than that, I can't see the Titans winning this one.
Buccs over Chiefs - I just think that Tampa should be able to pull this one off at home.
Ravens over Cowboys - Both of these teams have alter egos but I think the Cowboys alter ego is the worse of the two, the Cowboys would have to win this game on the ground to open up for the passing game, other than that Romo will have another rough game.
Falcons over Raiders - The Falcons will keep rolling with their undefeated record, last week was probably the best chance for them to lose one. The Falcons do have a weakness against the run, but I haven't noticed McFadden having any stellar games lately.
Eagles over Lions - The Lions seem like they are missing something and the Eagles have been able to pull out wins at home this year.
Bengals over Browns - Bengals are just a better team.
Colts over Jets - The Colts look good, the Jets look bad, easy pick if you ask me.
Cardinals over Bills - The Bills look really bad right about now, and the Cardinals still have a pretty good defense. The Cardinals should be able to bounce back from that road loss with a win at home this week.
Seahawks over Patriots - This is my underdog pick of the week. I'm going with the 12th man and the defense to show up against the Patriots this weekend. The Patriots have been able to play better when they can get the running game going, against the Seahawks defense I think that running game will suffer.
The San Francisco 49ers over GiAints - I explained this above.
Vikings over the Redskins - I went back and forth with this one. The Skins usually win when I pick against them and lose when I pick them so who knows what will happen. The Vikings have looked like they have a good offense and the defense has also showed up lately, where as the Skins have way more offense than they do defense right now so I'm going with the more balanced team.
Texans over Packers - You would think the Packers would bounce back this week, but they have a tough match up against a team that knows how to play solid defense, get to the QB, and run the ball effectively to set up for the play action pass so I think they will have to wait a game or two for that bounce back. The Texans still look like the complete package even after a not so impressive game against the Jets. Texans stay undefeated for another week.
Broncos over Chargers - Tough pick, I flipped a coin. Plus Peyton is more dependable than Phillip.
Ryan has set a quick early pace while leading the Falcons to a 2-0 record. He leads the NFL in Total QBR by a wide margin thanks to five passing touchdowns, one rushing touchdown, two sacks and zero turnovers. He has never finished a season with 30-plus scoring passes or a completion percentage higher than 62.5. His quick start and the Falcons' overall strength put Ryan in position to enjoy a career year both in production and team success. 
Smith ranks second only to Ryan in success rate, defined by ESPN's analytics department as those producing gains in expected points. Like Ryan, Smith has zero turnovers through two games. Despite taking seven sacks, Smith ranks second only to Ryan in QBR among quarterbacks with enough attempts to qualify. He's at 81.9 out of 100 after finishing last season ranked 22nd at 45.8 (50 is average, suggesting the 49ers won largely for factors beyond QB production). 
All MVP Watch candidates are not created the same. Those with lesser career credentials must be producing at a high level to earn spots on the list. The few players with Rodgers' credentials get the benefit of the doubt in the absence of their usual production, especially early in the season. Rodgers has yet to get going, but he has also faced two rugged defenses. The trend continues when the Packers visit Seattle in Week 3. Rodgers' production should pick up against New Orleans (Week 4) and Indianapolis (Week 5) before a tough matchup at Houston (Week 6). 
Rivers makes his 2012 debut on the list. He ranks second to Christian Ponder in completion percentage (73.8) and has led the Chargers to their first 2-0 start since the 2006 team won its final 10 games to finish 14-2. A home game against Ryan's Falcons provides Rivers with a stage to prove he belongs on this list, and possibly higher than fourth. Trips to Kansas City and New Orleans await from there, part of a road schedule that appears manageable for Rivers and San Diego. 
A stunning 510-yard passing performance returns Manning to the list after a week away. Check out this note from ESPN Stats & Information: "Since the start of 2011, Manning is 18-of-28 (64.3 percent) with eight touchdowns and no interceptions in the fourth quarter on throws more than 20 yards downfield. In the first three quarters, Manning is 25-of-70 (35.7 percent) with four touchdowns and four interceptions on such throws." What we're saying, pretty much, is that Manning is clutch. 
Brady had a tough time solving Arizona's defense and now he must adjust to life without injured tight end Aaron Hernandez. He ranks only 23rd in Total QBR to this point. A trip to Baltimore in Week 3 wouldn't seem to help. Brady has seven picks in his past three games against the Ravens, counting the playoffs. He took four sacks against the Cardinals. That was his total through Week 4 last season. New England has three of its next four on the road. 
This spot feels a little high for Newton based on his production to this point and the Panthers' 1-1 record. Let's check back in a week to see how well he fared in his first career matchup against the Giants. The game is at Carolina, which should help. Newton was a 60 percent passer last season. He's closer to 70 percent through two games. 
Matthews becomes the first defensive player to appear on the MVP Watch list this season. No defensive player has won The Associated Press version of the award since Lawrence Taylor a quarter century ago. The trend isn't going to change, most likely, in this era of increased pass production. But with 3.5 sacks against the Bears and six through two games, he has stood out. From the Elias Sports Bureau: "Since sacks became an official stat in 1982, Matthews is just the sixth player to have at least six sacks in his team's first two games and the only player to do it twice." 
It's looking like Griffin will have to carry more of the Redskins' weight after the team suffered devastating injuries on defense during its 31-28 defeat at St. Louis. He appears capable of handling the added pressure. The Redskins have put up 68 points through two games, both on the road. They play three of their next four at home. From Elias: Griffin joins Newton and Jake Delhomme as the only quarterbacks since 1970 with three passing touchdowns and two rushing touchdowns over his first two career games. 
The running game hasn't gotten much going for Pittsburgh to this point. Only two teams are averaging fewer yards per carry than the Steelers are averaging. From ESPN Stats & Information: Roethlisberger's third-down production this season leaves him ranked first or second in passing yards, passing first downs, passing touchdowns, completion percentage and QBR. Roethlisberger has completed 19 of 25 third-down passes for 251 yards and three scores with no picks. 
